Impairment of carbonic anhydrase IX ectodomain cleavage reinforces tumorigenic and metastatic phenotype of cancer cells

BACKGROUND: Carbonic anhydrase IX (CA IX) is a hypoxia-induced enzyme regulating tumour pH and facilitating cell migration/invasion. It is primarily expressed as a transmembrane cell-surface protein, but its ectodomain can be shed by ADAM17 to extracellular space. This study aims to elucidate the im...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Kajanova, Ivana, Zatovicova, Miriam, Jelenska, Lenka, Sedlakova, Olga, Barathova, Monika, Csaderova, Lucia, Debreova, Michaela, Lukacikova, Lubomira, Grossmannova, Katarina, Labudova, Martina, Golias, Tereza, Svastova, Eliska, Ludwig, Andreas, Muller, Petr, Vojtesek, Borivoj, Pastorek, Jaromir, Pastorekova, Silvia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7250822/
https://ncbi.nlm.nih.gov/pubmed/32210366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-020-0804-z
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