Apoptosis-induced ectodomain shedding of hypoxia-regulated carbonic anhydrase IX from tumor cells: a double-edged response to chemotherapy

BACKGROUND: Carbonic anhydrase IX (CA IX) is a tumor-associated, highly active, transmembrane carbonic anhydrase isoform regulated by hypoxia and implicated in pH control and adhesion-migration-invasion. CA IX ectodomain (ECD) is shed from the tumor cell surface to serum/plasma of patients, where it...

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Enregistré dans:
Détails bibliographiques
Publié dans:BMC Cancer
Auteurs principaux: Vidlickova, Ivana, Dequiedt, Franck, Jelenska, Lenka, Sedlakova, Olga, Pastorek, Michal, Stuchlik, Stanislav, Pastorek, Jaromir, Zatovicova, Miriam, Pastorekova, Silvia
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4799595/
https://ncbi.nlm.nih.gov/pubmed/26993100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2267-4
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