Ectodomain shedding of the hypoxia-induced carbonic anhydrase IX is a metalloprotease-dependent process regulated by TACE/ADAM17

Carbonic anhydrase IX (CA IX) is a transmembrane protein whose expression is strongly induced by hypoxia in a broad spectrum of human tumours. It is a highly active enzyme functionally involved in both pH control and cell adhesion. Its presence in tumours usually indicates poor prognosis. Ectodomain...

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Autores principales: Zatovicova, M, Sedlakova, O, Svastova, E, Ohradanova, A, Ciampor, F, Arribas, J, Pastorek, J, Pastorekova, S
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2005
Materias:
Translational Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361518/
https://ncbi.nlm.nih.gov/pubmed/16278664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602861
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