CAIX Regulates Invadopodia Formation through Both a pH-Dependent Mechanism and Interplay with Actin Regulatory Proteins

Tumor metastasis is tightly linked with invasive membrane protrusions, invadopodia, formed by actively invading tumor cells. Hypoxia and pH modulation play a role in the invadopodia formation and in their matrix degradation ability. Tumor-associated carbonic anhydrase IX (CAIX), induced by hypoxia,...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Debreova, Michaela, Csaderova, Lucia, Burikova, Monika, Lukacikova, Lubomira, Kajanova, Ivana, Sedlakova, Olga, Kery, Martin, Kopacek, Juraj, Zatovicova, Miriam, Bizik, Jozef, Pastorekova, Silvia, Svastova, Eliska
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6600150/
https://ncbi.nlm.nih.gov/pubmed/31167468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20112745
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