Preclinical Incorporation Dosimetry of [(18)F]FACH—A Novel (18)F-Labeled MCT1/MCT4 Lactate Transporter Inhibitor for Imaging Cancer Metabolism with PET

Overexpression of monocarboxylate transporters (MCTs) has been shown for a variety of human cancers (e.g., colon, brain, breast, and kidney) and inhibition resulted in intracellular lactate accumulation, acidosis, and cell death. Thus, MCTs are promising targets to investigate tumor cancer metabolis...

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Bibliographic Details
Published in:Molecules
Main Authors: Sattler, Bernhard, Kranz, Mathias, Wenzel, Barbara, Jain, Nalin T., Moldovan, Rareş-Petru, Toussaint, Magali, Deuther-Conrad, Winnie, Ludwig, Friedrich-Alexander, Teodoro, Rodrigo, Sattler, Tatjana, Sadeghzadeh, Masoud, Sabri, Osama, Brust, Peter
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7248880/
https://ncbi.nlm.nih.gov/pubmed/32357571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25092024
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