Preclinical Incorporation Dosimetry of [(18)F]FACH—A Novel (18)F-Labeled MCT1/MCT4 Lactate Transporter Inhibitor for Imaging Cancer Metabolism with PET

Overexpression of monocarboxylate transporters (MCTs) has been shown for a variety of human cancers (e.g., colon, brain, breast, and kidney) and inhibition resulted in intracellular lactate accumulation, acidosis, and cell death. Thus, MCTs are promising targets to investigate tumor cancer metabolis...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Sattler, Bernhard, Kranz, Mathias, Wenzel, Barbara, Jain, Nalin T., Moldovan, Rareş-Petru, Toussaint, Magali, Deuther-Conrad, Winnie, Ludwig, Friedrich-Alexander, Teodoro, Rodrigo, Sattler, Tatjana, Sadeghzadeh, Masoud, Sabri, Osama, Brust, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7248880/
https://ncbi.nlm.nih.gov/pubmed/32357571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25092024
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