SPOP promotes ubiquitination and degradation of LATS1 to enhance kidney cancer progression

BACKGROUND: Emerging evidence has demonstrated that SPOP functions as an oncoprotein in kidney cancer to promote tumorigenesis by ubiquitination-mediated degradation of multiple regulators of cellular proliferation and apoptosis. However, the detailed molecular mechanism underlying the oncogenic rol...

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Bibliographic Details
Published in:EBioMedicine
Main Authors: Wang, Lixia, Lin, Min, Chu, Man, Liu, Yi, Ma, Jia, He, Youhua, Wang, Zhi-wei
Format: Artigo
Language:Inglês
Published: Elsevier 2020
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Research paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7248661/
https://ncbi.nlm.nih.gov/pubmed/32460168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.102795
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