SPOP promotes ubiquitination and degradation of MyD88 to suppress the innate immune response

As a canonical adaptor for the Toll-like receptor (TLR) family, myeloid differentiation primary response protein 88 (MyD88) has crucial roles in host defense against infection by microbial pathogens, and its dysregulation might induce autoimmune diseases. Here, we demonstrate that the chicken Cullin...

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Udgivet i:PLoS Pathog
Main Authors: Li, Qinghe, Wang, Fei, Wang, Qiao, Zhang, Na, Zheng, Jumei, Zheng, Maiqing, Liu, Ranran, Cui, Huanxian, Wen, Jie, Zhao, Guiping
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7224567/
https://ncbi.nlm.nih.gov/pubmed/32365080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008188
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