SPOP promotes ubiquitination and degradation of MyD88 to suppress the innate immune response

As a canonical adaptor for the Toll-like receptor (TLR) family, myeloid differentiation primary response protein 88 (MyD88) has crucial roles in host defense against infection by microbial pathogens, and its dysregulation might induce autoimmune diseases. Here, we demonstrate that the chicken Cullin...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS Pathog
Prif Awduron: Li, Qinghe, Wang, Fei, Wang, Qiao, Zhang, Na, Zheng, Jumei, Zheng, Maiqing, Liu, Ranran, Cui, Huanxian, Wen, Jie, Zhao, Guiping
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2020
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7224567/
https://ncbi.nlm.nih.gov/pubmed/32365080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008188
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