SPOP promotes ubiquitination and degradation of MyD88 to suppress the innate immune response

As a canonical adaptor for the Toll-like receptor (TLR) family, myeloid differentiation primary response protein 88 (MyD88) has crucial roles in host defense against infection by microbial pathogens, and its dysregulation might induce autoimmune diseases. Here, we demonstrate that the chicken Cullin...

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Библиографические подробности
Опубликовано в: :PLoS Pathog
Главные авторы: Li, Qinghe, Wang, Fei, Wang, Qiao, Zhang, Na, Zheng, Jumei, Zheng, Maiqing, Liu, Ranran, Cui, Huanxian, Wen, Jie, Zhao, Guiping
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2020
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7224567/
https://ncbi.nlm.nih.gov/pubmed/32365080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008188
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