SPOP negatively regulates Toll-like receptor-induced inflammation by disrupting MyD88 self-association

Toll-like receptor (TLR) signaling pathways need to be tightly controlled to avoid excessive inflammation and unwanted damage to the host. Myeloid differentiation primary response gene 88 (MyD88) is a critical adaptor of TLR signaling. Here, we identified the speckle-type POZ protein (SPOP) as a MyD...

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Veröffentlicht in:Cell Mol Immunol
Hauptverfasser: Hu, Yun-Hong, Wang, Yang, Wang, Fei, Dong, Yan-Ming, Jiang, Wan-Ling, Wang, Ya-Ping, Zhong, Xing, Ma, Li-Xin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8245473/
https://ncbi.nlm.nih.gov/pubmed/32235916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-020-0411-1
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