SPOP promotes ubiquitination and degradation of MyD88 to suppress the innate immune response

As a canonical adaptor for the Toll-like receptor (TLR) family, myeloid differentiation primary response protein 88 (MyD88) has crucial roles in host defense against infection by microbial pathogens, and its dysregulation might induce autoimmune diseases. Here, we demonstrate that the chicken Cullin...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Li, Qinghe, Wang, Fei, Wang, Qiao, Zhang, Na, Zheng, Jumei, Zheng, Maiqing, Liu, Ranran, Cui, Huanxian, Wen, Jie, Zhao, Guiping
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7224567/
https://ncbi.nlm.nih.gov/pubmed/32365080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008188
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