Increased cerebrospinal fluid amyloid-β during sleep deprivation in healthy middle-aged adults is not due to stress or circadian disruption

BACKGROUND: Concentrations of soluble amyloid-β oscillate with the sleep-wake cycle in the interstitial fluid of mice and cerebrospinal fluid of humans. Further, the concentration of amyloid-β in cerebrospinal fluid increases during sleep deprivation. Stress and disruption of the circadian clock are...

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Veröffentlicht in:J Alzheimers Dis
Hauptverfasser: Blattner, Margaret S., Panigrahi, Sunil K., Toedebusch, Cristina D., Hicks, Terry J., McLeland, Jennifer S., Banks, Ian R., Schaibley, Claire, Ovod, Vitaliy, Mawuenyega, Kwasi G., Bateman, Randall J., Wardlaw, Sharon L., Lucey, Brendan P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7246155/
https://ncbi.nlm.nih.gov/pubmed/32250301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-191122
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