Increased cerebrospinal fluid amyloid-β during sleep deprivation in healthy middle-aged adults is not due to stress or circadian disruption

BACKGROUND: Concentrations of soluble amyloid-β oscillate with the sleep-wake cycle in the interstitial fluid of mice and cerebrospinal fluid of humans. Further, the concentration of amyloid-β in cerebrospinal fluid increases during sleep deprivation. Stress and disruption of the circadian clock are...

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Detalhes bibliográficos
Publicado no:J Alzheimers Dis
Main Authors: Blattner, Margaret S., Panigrahi, Sunil K., Toedebusch, Cristina D., Hicks, Terry J., McLeland, Jennifer S., Banks, Ian R., Schaibley, Claire, Ovod, Vitaliy, Mawuenyega, Kwasi G., Bateman, Randall J., Wardlaw, Sharon L., Lucey, Brendan P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7246155/
https://ncbi.nlm.nih.gov/pubmed/32250301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-191122
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