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Sleep deprivation affects tau phosphorylation in human cerebrospinal fluid

Tau hyperphosphorylation is an early step in tau-mediated neurodegeneration and is associated with intracellular aggregation of tau as neurofibrillary tangles, neuronal and synaptic loss, and eventual cognitive dysfunction in Alzheimer’s disease. Sleep loss increases the cerebrospinal fluid concentr...

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Bibliografische gegevens
Gepubliceerd in:Ann Neurol
Hoofdauteurs: Barthélemy, Nicolas R., Liu, Haiyan, Lu, William, Kotzbauer, Paul T., Bateman, Randall J., Lucey, Brendan P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7289061/
https://ncbi.nlm.nih.gov/pubmed/32057125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.25702
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