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Tau Phosphorylation Rates Measured by Mass Spectrometry Differ in the Intracellular Brain vs. Extracellular Cerebrospinal Fluid Compartments and Are Differentially Affected by Alzheimer’s Disease

Tau protein aggregation into neurofibrillary tangles in the central nervous system contributes to the etiology of certain neurodegenerative disorders, including Alzheimer’s disease (AD). Though the mechanism of tau destabilization is not fully understood yet, tau protein has been found to be hyperph...

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Detalhes bibliográficos
Publicado no:Front Aging Neurosci
Main Authors: Barthélemy, Nicolas R., Mallipeddi, Nipun, Moiseyev, Paul, Sato, Chihiro, Bateman, Randall J.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6537657/
https://ncbi.nlm.nih.gov/pubmed/31178717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2019.00121
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