Diverse, evolving conformer populations drive distinct phenotypes in frontotemporal lobar degeneration caused by the same MAPT-P301L mutation

Tau protein accumulation is a common denominator of major dementias, but this process is inhomogeneous, even when triggered by the same germline mutation. We considered stochastic misfolding of human tau conformers followed by templated conversion of native monomers as an underlying mechanism and de...

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Bibliografske podrobnosti
izdano v:Acta Neuropathol
Main Authors: Daude, Nathalie, Kim, Chae, Kang, Sang-Gyun, Eskandari-Sedighi, Ghazaleh, Haldiman, Tracy, Yang, Jing, Fleck, Shelaine C., Gomez-Cardona, Erik, Han, Zhuang Zhuang, Borrego-Ecija, Sergi, Wohlgemuth, Serene, Julien, Olivier, Wille, Holger, Molina-Porcel, Laura, Gelpi, Ellen, Safar, Jiri G., Westaway, David
Format: Artigo
Jezik:Inglês
Izdano: Springer Berlin Heidelberg 2020
Teme:
Original Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7244472/
https://ncbi.nlm.nih.gov/pubmed/32219515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-020-02148-4
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