Mitotic defects lead to neuronal aneuploidy and apoptosis in frontotemporal lobar degeneration caused by MAPT mutations

Mutant Tau (MAPT) can lead to frontotemporal lobar degeneration (FTLD). Previous studies associated MAPT mutations and altered function with aneuploidy and chromosome instability in human lymphocytes and in Drosophila development. Here we examine whether FTLD-causing mutations in human MAPT induce a...

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Detalhes bibliográficos
Publicado no:Mol Biol Cell
Main Authors: Caneus, Julbert, Granic, Antoneta, Rademakers, Rosa, Dickson, Dennis W., Coughlan, Christina M., Chial, Heidi J., Potter, Huntington
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004587/
https://ncbi.nlm.nih.gov/pubmed/29282277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E17-01-0031
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