Mitotic defects lead to neuronal aneuploidy and apoptosis in frontotemporal lobar degeneration caused by MAPT mutations

Mutant Tau (MAPT) can lead to frontotemporal lobar degeneration (FTLD). Previous studies associated MAPT mutations and altered function with aneuploidy and chromosome instability in human lymphocytes and in Drosophila development. Here we examine whether FTLD-causing mutations in human MAPT induce a...

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Veröffentlicht in:Mol Biol Cell
Hauptverfasser: Caneus, Julbert, Granic, Antoneta, Rademakers, Rosa, Dickson, Dennis W., Coughlan, Christina M., Chial, Heidi J., Potter, Huntington
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004587/
https://ncbi.nlm.nih.gov/pubmed/29282277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E17-01-0031
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