Brain MR Spectroscopy Changes Precede Frontotemporal Lobar Degeneration Phenoconversion in Mapt Mutation Carriers

BACKGROUND AND PURPOSE: The objective of this study was to longitudinally investigate the trajectory of change in (1)H MRS measurements in asymptomatic MAPT mutation carriers who became symptomatic during follow‐up, and to determine the time at which the neurochemical alterations accelerated during...

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Veröffentlicht in:J Neuroimaging
Hauptverfasser: Chen, Qin, Boeve, Bradley F., Tosakulwong, Nirubol, Lesnick, Timothy, Brushaber, Danielle, Dheel, Christina, Fields, Julie, Forsberg, Leah, Gavrilova, Ralitza, Gearhart, Debra, Haley, Dana, Gunter, Jeffrey L., Graff‐Radford, Jonathan, Jones, David, Knopman, David, Graff‐Radford, Neill, Kraft, Ruth, Lapid, Maria, Rademakers, Rosa, Wszolek, Zbigniew K., Rosen, Howie, Boxer, Adam L., Kantarci, Kejal
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731148/
https://ncbi.nlm.nih.gov/pubmed/31173437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jon.12642
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