Trajectory of Lobar Atrophy in Asymptomatic and Symptomatic GRN Mutation Carriers: a Longitudinal MRI Study

Loss-of-function mutations in the progranulin gene (GRN) are one of the major causes of familial frontotemporal lobar degeneration (FTLD). Our objective was to determine the rates and trajectories of lobar cortical atrophy from longitudinal structural MRI in both asymptomatic and symptomatic GRN mut...

Full description

Saved in:
Bibliographic Details
Published in:Neurobiol Aging
Main Authors: Chen, Qin, Boeve, Bradley F., Senjem, Matthew, Tosakulwong, Nirubol, Lesnick, Timothy, Brushaber, Danielle, Dheel, Christina, Fields, Julie, Forsberg, Leah, Gavrilova, Ralitza, Gearhart, Debra, Graff-Radford, Jonathan, Graff-Radford, Neill, Jack, Clifford R, Jones, David, Knopman, David, Kremers, Walter K., Lapid, Maria, Rademakers, Rosa, Ramos, Eliana Marisa, Syrjanen, Jeremy, Boxer, Adam L., Rosen, Howie, Wszolek, Zbigniew K., Kantarci, Kejal
Format: Artigo
Language:Inglês
Published: 2019
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7767622/
https://ncbi.nlm.nih.gov/pubmed/31918955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2019.12.004
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items