Diverse, evolving conformer populations drive distinct phenotypes in frontotemporal lobar degeneration caused by the same MAPT-P301L mutation

Tau protein accumulation is a common denominator of major dementias, but this process is inhomogeneous, even when triggered by the same germline mutation. We considered stochastic misfolding of human tau conformers followed by templated conversion of native monomers as an underlying mechanism and de...

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Publicat a:Acta Neuropathol
Autors principals: Daude, Nathalie, Kim, Chae, Kang, Sang-Gyun, Eskandari-Sedighi, Ghazaleh, Haldiman, Tracy, Yang, Jing, Fleck, Shelaine C., Gomez-Cardona, Erik, Han, Zhuang Zhuang, Borrego-Ecija, Sergi, Wohlgemuth, Serene, Julien, Olivier, Wille, Holger, Molina-Porcel, Laura, Gelpi, Ellen, Safar, Jiri G., Westaway, David
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2020
Matèries:
Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7244472/
https://ncbi.nlm.nih.gov/pubmed/32219515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-020-02148-4
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