Role of Coiled-Coil Registry Shifts in the Activation of Human Bicaudal D2 for Dynein Recruitment upon Cargo Binding

Dynein adaptors such as Bicaudal D2 (BicD2) recognize cargo for dyneindependent transport, and cargo-bound adaptors are required to activate dynein for processive transport, but the mechanism of action is unknown. Here we report the X-ray structure of the cargo-binding domain of human BicD2 and inve...

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Veröffentlicht in:J Phys Chem Lett
Hauptverfasser: Noell, Crystal R., Loh, Jia Ying, Debler, Erik W., Loftus, Kyle M., Cui, Heying, Russ, Blaine B., Zhang, Kaiqi, Goyal, Puja, Solmaz, Sozanne R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7243283/
https://ncbi.nlm.nih.gov/pubmed/31306018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpclett.9b01865
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