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Role of Coiled-Coil Registry Shifts in the Activation of Human Bicaudal D2 for Dynein Recruitment upon Cargo Binding
Dynein adaptors such as Bicaudal D2 (BicD2) recognize cargo for dyneindependent transport, and cargo-bound adaptors are required to activate dynein for processive transport, but the mechanism of action is unknown. Here we report the X-ray structure of the cargo-binding domain of human BicD2 and inve...
Shranjeno v:
| izdano v: | J Phys Chem Lett |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2019
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7243283/ https://ncbi.nlm.nih.gov/pubmed/31306018 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpclett.9b01865 |
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