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Role of Coiled-Coil Registry Shifts in the Activation of Human Bicaudal D2 for Dynein Recruitment upon Cargo Binding

Dynein adaptors such as Bicaudal D2 (BicD2) recognize cargo for dyneindependent transport, and cargo-bound adaptors are required to activate dynein for processive transport, but the mechanism of action is unknown. Here we report the X-ray structure of the cargo-binding domain of human BicD2 and inve...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Phys Chem Lett
Egile Nagusiak: Noell, Crystal R., Loh, Jia Ying, Debler, Erik W., Loftus, Kyle M., Cui, Heying, Russ, Blaine B., Zhang, Kaiqi, Goyal, Puja, Solmaz, Sozanne R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7243283/
https://ncbi.nlm.nih.gov/pubmed/31306018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpclett.9b01865
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