Nalaganje...

Coiled-coil registry shifts in the F684I mutant of Bicaudal D result in cargo-independent activation of dynein motility

The dynein adaptor Drosophila Bicaudal D (BicD) is auto-inhibited and activates dynein motility only after cargo is bound, but the underlying mechanism is elusive. In contrast, we show that the full-length BicD/F684I mutant activates dynein processivity even in the absence of cargo. Our X-ray struct...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Traffic
Main Authors: Cui, Heying, Ali, M. Yusuf, Goyal, Puja, Zhang, Kaiqi, Loh, Jia Ying, Trybus, Kathleen M., Solmaz, Sozanne R.
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7437983/
https://ncbi.nlm.nih.gov/pubmed/32378283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/tra.12734
Oznake: Označite
Brez oznak, prvi označite!