Nalaganje...
Coiled-coil registry shifts in the F684I mutant of Bicaudal D result in cargo-independent activation of dynein motility
The dynein adaptor Drosophila Bicaudal D (BicD) is auto-inhibited and activates dynein motility only after cargo is bound, but the underlying mechanism is elusive. In contrast, we show that the full-length BicD/F684I mutant activates dynein processivity even in the absence of cargo. Our X-ray struct...
Shranjeno v:
| izdano v: | Traffic |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2020
|
| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7437983/ https://ncbi.nlm.nih.gov/pubmed/32378283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/tra.12734 |
| Oznake: |
Označite
Brez oznak, prvi označite!
|