Llwytho...
Coiled-coil registry shifts in the F684I mutant of Bicaudal D result in cargo-independent activation of dynein motility
The dynein adaptor Drosophila Bicaudal D (BicD) is auto-inhibited and activates dynein motility only after cargo is bound, but the underlying mechanism is elusive. In contrast, we show that the full-length BicD/F684I mutant activates dynein processivity even in the absence of cargo. Our X-ray struct...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Traffic |
|---|---|
| Prif Awduron: | , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2020
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7437983/ https://ncbi.nlm.nih.gov/pubmed/32378283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/tra.12734 |
| Tagiau: |
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