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Cohesin Causes Replicative DNA Damage by Trapping DNA Topological Stress
DNA topological stress inhibits DNA replication fork (RF) progression and contributes to DNA replication stress. In Saccharomyces cerevisiae, we demonstrate that centromeric DNA and the rDNA array are especially vulnerable to DNA topological stress during replication. The activity of the SMC complex...
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| Publié dans: | Mol Cell |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Cell Press
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7242899/ https://ncbi.nlm.nih.gov/pubmed/32259483 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.03.013 |
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