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Role of DNA damage response pathways in preventing carcinogenesis caused by intrinsic replication stress
Defective DNA replication can result in genomic instability, cancer, and developmental defects. To understand the roles of DNA damage response (DDR) genes on carcinogenesis in mutants defective for core DNA replication components, we utilized the Mcm4(Chaos3/Chaos3) (“Chaos3”) mouse model which, by...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3936004/ https://ncbi.nlm.nih.gov/pubmed/23975433 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.339 |
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