Incremental Genetic Perturbations to MCM2-7 Expression and Subcellular Distribution Reveal Exquisite Sensitivity of Mice to DNA Replication Stress

Mutations causing replication stress can lead to genomic instability (GIN). In vitro studies have shown that drastic depletion of the MCM2-7 DNA replication licensing factors, which form the replicative helicase, can cause GIN and cell proliferation defects that are exacerbated under conditions of r...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Chuang, Chen-Hua, Wallace, Marsha D., Abratte, Christian, Southard, Teresa, Schimenti, John C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2010
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936539/
https://ncbi.nlm.nih.gov/pubmed/20838603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001110
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