Incremental Genetic Perturbations to MCM2-7 Expression and Subcellular Distribution Reveal Exquisite Sensitivity of Mice to DNA Replication Stress

Mutations causing replication stress can lead to genomic instability (GIN). In vitro studies have shown that drastic depletion of the MCM2-7 DNA replication licensing factors, which form the replicative helicase, can cause GIN and cell proliferation defects that are exacerbated under conditions of r...

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Bibliografiske detaljer
Main Authors: Chuang, Chen-Hua, Wallace, Marsha D., Abratte, Christian, Southard, Teresa, Schimenti, John C.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936539/
https://ncbi.nlm.nih.gov/pubmed/20838603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001110
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