Checkpoint inhibition of origin firing prevents DNA topological stress

A universal feature of DNA damage and replication stress in eukaryotes is the activation of a checkpoint-kinase response. In S-phase, the checkpoint inhibits replication initiation, yet the function of this global block to origin firing remains unknown. To establish the physiological roles of this a...

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Publicado en:Genes Dev
Autores principales: Morafraile, Esther C., Hänni, Christine, Allen, George, Zeisner, Theresa, Clarke, Caroline, Johnson, Mark C., Santos, Miguel M., Carroll, Lauren, Minchell, Nicola E., Baxter, Jonathan, Banks, Peter, Lydall, Dave, Zegerman, Philip
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824463/
https://ncbi.nlm.nih.gov/pubmed/31624083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.328682.119
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