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Thyrocyte cell survival and adaptation to chronic endoplasmic reticulum stress due to misfolded thyroglobulin

The large secretory glycoprotein thyroglobulin is the primary translation product of thyroid follicular cells. This difficult-to-fold protein is susceptible to structural alterations that disable export of the misfolded thyroglobulin from the endoplasmic reticulum (ER), which is a known cause of con...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Morishita, Yoshiaki, Kabil, Omer, Young, Kelly Z., Kellogg, Aaron P., Chang, Amy, Arvan, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7242714/
https://ncbi.nlm.nih.gov/pubmed/32241916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012656
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