Spontaneous glycan reattachment following N-glycanase treatment of influenza and HIV vaccine antigens

In cells asparagine/N-linked glycans are added to glycoproteins co-translationally, in an attachment process that supports proper folding of the nascent polypeptide. We find that following pruning of N-glycan by the amidase PNGase F, the principle influenza vaccine antigen and major viral spike prot...

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Pubblicato in:J Proteome Res
Autori principali: Keating, Celina L., Kuhn, Eric, Bals, Julia, Cocco, Alexandra R., Yousif, Ashraf S., Matysiak, Colette, Sangesland, Maya, Ronsard, Larance, Smoot, Matthew, Moreno, Thalia Bracamonte, Okonkwo, Vintus, Setliff, Ian, Georgiev, Ivelin, Balazs, Alejandro B., Carr, Steven A., Lingwood, Daniel
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7241686/
https://ncbi.nlm.nih.gov/pubmed/31913636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jproteome.9b00620
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