Spontaneous glycan reattachment following N-glycanase treatment of influenza and HIV vaccine antigens

In cells asparagine/N-linked glycans are added to glycoproteins co-translationally, in an attachment process that supports proper folding of the nascent polypeptide. We find that following pruning of N-glycan by the amidase PNGase F, the principle influenza vaccine antigen and major viral spike prot...

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Udgivet i:J Proteome Res
Main Authors: Keating, Celina L., Kuhn, Eric, Bals, Julia, Cocco, Alexandra R., Yousif, Ashraf S., Matysiak, Colette, Sangesland, Maya, Ronsard, Larance, Smoot, Matthew, Moreno, Thalia Bracamonte, Okonkwo, Vintus, Setliff, Ian, Georgiev, Ivelin, Balazs, Alejandro B., Carr, Steven A., Lingwood, Daniel
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7241686/
https://ncbi.nlm.nih.gov/pubmed/31913636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jproteome.9b00620
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