Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses

Exposure to a pathogen elicits an adaptive immune response aimed to control and eradicate. Interrogating the abundance and specificity of the naive B cell repertoire contributes to understanding how to potentially elicit protective responses. Here, we isolated naive B cells from 8 seronegative human...

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Veröffentlicht in:bioRxiv
Hauptverfasser: Feldman, Jared, Bals, Julia, Altomare, Clara G., St. Denis, Kerri, Lam, Evan C., Hauser, Blake M., Ronsard, Larance, Sangesland, Maya, Moreno, Thalia Bracamonte, Okonkwo, Vintus, Hartojo, Nathania, Balazs, Alejandro B., Bajic, Goran, Lingwood, Daniel, Schmidt, Aaron G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7885909/
https://ncbi.nlm.nih.gov/pubmed/33594359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.02.02.429458
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