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Effect of the His-Tag Location on Decapping Scavenger Enzymes and Their Hydrolytic Activity toward Cap Analogs

[Image: see text] Decapping scavenger enzymes (DcpSs) are important players in mRNA degradation machinery and conserved in eukaryotes. Importantly, human DcpS is the recognized target for spinal muscular atrophy (SMA) and acute myeloid leukemia (AML) therapy, and has recently been connected to devel...

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Detalhes bibliográficos
Publicado no:ACS Omega
Main Authors: Ferenc-Mrozek, Aleksandra, Bojarska, Elzbieta, Stepinski, Janusz, Darzynkiewicz, Edward, Lukaszewicz, Maciej
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7240826/
https://ncbi.nlm.nih.gov/pubmed/32455195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.0c00304
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