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Synergistic actions of v-SNARE transmembrane domains and membrane-curvature modifying lipids in neurotransmitter release

Vesicle fusion is mediated by assembly of SNARE proteins between opposing membranes. While previous work suggested an active role of SNARE transmembrane domains (TMDs) in promoting membrane merger (Dhara et al., 2016), the underlying mechanism remained elusive. Here, we show that naturally-occurring...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Dhara, Madhurima, Mantero Martinez, Maria, Makke, Mazen, Schwarz, Yvonne, Mohrmann, Ralf, Bruns, Dieter
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7239655/
https://ncbi.nlm.nih.gov/pubmed/32391794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.55152
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