A mechanism for exocytotic arrest by the Complexin C-terminus

ComplexinII (CpxII) inhibits non-synchronized vesicle fusion, but the underlying mechanisms have remained unclear. Here, we provide evidence that the far C-terminal domain (CTD) of CpxII interferes with SNARE assembly, thereby arresting tonic exocytosis. Acute infusion of a CTD-derived peptide into...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Makke, Mazen, Mantero Martinez, Maria, Gaya, Surya, Schwarz, Yvonne, Frisch, Walentina, Silva-Bermudez, Lina, Jung, Martin, Mohrmann, Ralf, Dhara, Madhurima, Bruns, Dieter
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6075865/
https://ncbi.nlm.nih.gov/pubmed/30044227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.38981
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