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The SNAP-25 linker supports fusion intermediates by local lipid interactions
SNAP-25 is an essential component of SNARE complexes driving fast Ca(2+)-dependent exocytosis. Yet, the functional implications of the tandem-like structure of SNAP-25 are unclear. Here, we have investigated the mechanistic role of the acylated “linker” domain that concatenates the two SNARE motifs...
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| Publicado en: | eLife |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
eLife Sciences Publications, Ltd
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6422494/ https://ncbi.nlm.nih.gov/pubmed/30883328 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.41720 |
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