Structural basis for distinct operational modes and protease activation in AAA+ protease Lon

Substrate-bound structures of AAA+ protein translocases reveal a conserved asymmetric spiral staircase architecture wherein a sequential ATP hydrolysis cycle drives hand-over-hand substrate translocation. However, this configuration is unlikely to represent the full conformational landscape of these...

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Pubblicato in:Sci Adv
Autori principali: Shin, Mia, Puchades, Cristina, Asmita, Ananya, Puri, Neha, Adjei, Eric, Wiseman, R. Luke, Karzai, A. Wali, Lander, Gabriel C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Association for the Advancement of Science 2020
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7239648/
https://ncbi.nlm.nih.gov/pubmed/32490208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba8404
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