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Unique structural features of the mitochondrial AAA+ protease AFG3L2 reveal the molecular basis for activity in health and disease

Mitochondrial AAA+ quality control proteases regulate diverse aspects of mitochondrial biology through specialized protein degradation, but the underlying mechanisms of these enzymes remain poorly defined. The mitochondrial AAA+ protease AFG3L2 is of particular interest, as genetic mutations localiz...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Puchades, Cristina, Ding, Bojian, Song, Albert, Wiseman, R. Luke, Lander, Gabriel C., Glynn, Steven E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731152/
https://ncbi.nlm.nih.gov/pubmed/31327635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.06.016
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