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Cryo-EM reveals integrin-mediated TGF-β activation without release from latent TGF-β
Integrin αvβ8 binds with exquisite specificity to latent transforming growth factor-b (L-TGF-β). This binding is essential for activating L-TGF-β presented by a variety of cell types. Inhibiting αvβ8-mediated TGF-β activation blocks immunosuppressive regulatory T-cell differentiation, which is a pot...
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| 出版年: | Cell |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7238552/ https://ncbi.nlm.nih.gov/pubmed/31955848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.12.030 |
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