Integrin αvβ8–expressing tumor cells evade host immunity by regulating TGF-β activation in immune cells

TGF-β is a promising immunotherapeutic target. It is expressed ubiquitously in a latent form that must be activated to function. Determination of where and how latent TGF-β (L-TGF-β) is activated in the tumor microenvironment could facilitate cell- and mechanism-specific approaches to immunotherapeu...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Takasaka, Naoki, Seed, Robert I., Cormier, Anthony, Bondesson, Andrew J., Lou, Jianlong, Elattma, Ahmed, Ito, Saburo, Yanagisawa, Haruhiko, Hashimoto, Mitsuo, Ma, Royce, Levine, Michelle D., Publicover, Jean, Potts, Rashaun, Jespersen, Jillian M., Campbell, Melody G., Conrad, Fraser, Marks, James D., Cheng, Yifan, Baron, Jody L., Nishimura, Stephen L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237456/
https://ncbi.nlm.nih.gov/pubmed/30333313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.122591
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