Integrin αvβ8–expressing tumor cells evade host immunity by regulating TGF-β activation in immune cells

TGF-β is a promising immunotherapeutic target. It is expressed ubiquitously in a latent form that must be activated to function. Determination of where and how latent TGF-β (L-TGF-β) is activated in the tumor microenvironment could facilitate cell- and mechanism-specific approaches to immunotherapeu...

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Publicado en:JCI Insight
Main Authors: Takasaka, Naoki, Seed, Robert I., Cormier, Anthony, Bondesson, Andrew J., Lou, Jianlong, Elattma, Ahmed, Ito, Saburo, Yanagisawa, Haruhiko, Hashimoto, Mitsuo, Ma, Royce, Levine, Michelle D., Publicover, Jean, Potts, Rashaun, Jespersen, Jillian M., Campbell, Melody G., Conrad, Fraser, Marks, James D., Cheng, Yifan, Baron, Jody L., Nishimura, Stephen L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237456/
https://ncbi.nlm.nih.gov/pubmed/30333313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.122591
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