Integrin αvβ8–expressing tumor cells evade host immunity by regulating TGF-β activation in immune cells

TGF-β is a promising immunotherapeutic target. It is expressed ubiquitously in a latent form that must be activated to function. Determination of where and how latent TGF-β (L-TGF-β) is activated in the tumor microenvironment could facilitate cell- and mechanism-specific approaches to immunotherapeu...

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Vydáno v:JCI Insight
Hlavní autoři: Takasaka, Naoki, Seed, Robert I., Cormier, Anthony, Bondesson, Andrew J., Lou, Jianlong, Elattma, Ahmed, Ito, Saburo, Yanagisawa, Haruhiko, Hashimoto, Mitsuo, Ma, Royce, Levine, Michelle D., Publicover, Jean, Potts, Rashaun, Jespersen, Jillian M., Campbell, Melody G., Conrad, Fraser, Marks, James D., Cheng, Yifan, Baron, Jody L., Nishimura, Stephen L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237456/
https://ncbi.nlm.nih.gov/pubmed/30333313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.122591
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