Cryo-EM reveals integrin-mediated TGF-β activation without release from latent TGF-β

Integrin αvβ8 binds with exquisite specificity to latent transforming growth factor-b (L-TGF-β). This binding is essential for activating L-TGF-β presented by a variety of cell types. Inhibiting αvβ8-mediated TGF-β activation blocks immunosuppressive regulatory T-cell differentiation, which is a pot...

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Udgivet i:Cell
Main Authors: Campbell, Melody G., Cormier, Anthony, Ito, Saburo, Seed, Robert I., Bondesson, Andrew J., Lou, Jianlong, Marks, James D., Baron, Jody L., Cheng, Yifan, Nishimura, Stephen L.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7238552/
https://ncbi.nlm.nih.gov/pubmed/31955848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.12.030
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