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Total Synthesis and Biological Evaluation of Kakeromamide A and Its Analogues

Kakeromamide A (1), the first marine cyclopeptide inducing neural stem cells differentiation into astrocytes, was synthesized in 12 longest linear steps and 14% overall yield. Using this synthetic approach, four analogs of kakeromamide A were prepared and evaluated for neural differentiation- modula...

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Detalhes bibliográficos
Publicado no:Front Chem
Main Authors: Zhao, Meng, Xiao, Yi, Otsuka, Satoshi, Nakao, Yoichi, Guo, Yian, Ye, Tao
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7237762/
https://ncbi.nlm.nih.gov/pubmed/32478037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2020.00410
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