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Total Synthesis and Structural Reassignment of Laingolide A

The asymmetric total synthesis of four diastereomers of laingolide A was achieved, which led to the unambiguous assignment of the stereochemistry of the natural product. The salient features of the convergent, fully stereocontrolled approach were a copper-catalysed stereospecific Kumada-type couplin...

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Pubblicato in:Mar Drugs
Autori principali: Wu, Fusong, Zhang, Tao, Yu, Jie, Guo, Yian, Ye, Tao
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8145716/
https://ncbi.nlm.nih.gov/pubmed/33925490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md19050247
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