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Spatial regulation of GPR64/ADGRG2 signaling by β-arrestins and GPCR kinases

Mechanisms of activation, signaling, and trafficking of adhesion G protein–coupled receptors (aGPCRs) have remained largely unknown. Several aGPCRs, including GPR56/ADGRG1 and GPR64/ADGRG2, show increased activity in the absence of their N-terminal fragment (NTF). This constitutive signaling is plau...

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Detalhes bibliográficos
Publicado no:Ann N Y Acad Sci
Main Authors: Azimzadeh, Pedram, Talamantez-Lyburn, Sarah C., Chang, Katarina T., Inoue, Asuka, Balenga, Nariman
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236788/
https://ncbi.nlm.nih.gov/pubmed/31502283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nyas.14227
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