Factor H-Inspired Design of Peptide Biomarkers of the Complement C3d Protein

[Image: see text] C3d is a hallmark protein of the complement system, whose presence is critical to measure the progression of several immune diseases. Here, we propose to directly target C3d through small peptides mimicking the binding of its natural ligand, the complement regulator Factor H (FH)....

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: Harrison, Reed E. S., Zewde, Nehemiah T., Narkhede, Yogesh B., Hsu, Rohaine V., Morikis, Dimitrios, Vullev, Valentine I., Palermo, Giulia
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2020
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236534/
https://ncbi.nlm.nih.gov/pubmed/32435425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00663
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