Factor H-Inspired Design of Peptide Biomarkers of the Complement C3d Protein

[Image: see text] C3d is a hallmark protein of the complement system, whose presence is critical to measure the progression of several immune diseases. Here, we propose to directly target C3d through small peptides mimicking the binding of its natural ligand, the complement regulator Factor H (FH)....

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Udgivet i:ACS Med Chem Lett
Main Authors: Harrison, Reed E. S., Zewde, Nehemiah T., Narkhede, Yogesh B., Hsu, Rohaine V., Morikis, Dimitrios, Vullev, Valentine I., Palermo, Giulia
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2020
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236534/
https://ncbi.nlm.nih.gov/pubmed/32435425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00663
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