Spontaneous Embedding of DNA Mismatches Within the RNA:DNA Hybrid of CRISPR-Cas9

CRISPR-Cas9 is the forefront technology for editing the genome. In this system, the Cas9 protein is programmed with guide RNAs to process DNA sequences that match the guide RNA forming an RNA:DNA hybrid structure. However, the binding of DNA sequences that do not fully match the guide RNA can limit...

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Xehetasun bibliografikoak
Argitaratua izan da:Front Mol Biosci
Egile Nagusiak: Mitchell, Brandon P., Hsu, Rohaine V., Medrano, Marco A., Zewde, Nehemiah T., Narkhede, Yogesh B., Palermo, Giulia
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2020
Gaiak:
Molecular Biosciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7093078/
https://ncbi.nlm.nih.gov/pubmed/32258048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2020.00039
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