Spontaneous Embedding of DNA Mismatches Within the RNA:DNA Hybrid of CRISPR-Cas9

CRISPR-Cas9 is the forefront technology for editing the genome. In this system, the Cas9 protein is programmed with guide RNAs to process DNA sequences that match the guide RNA forming an RNA:DNA hybrid structure. However, the binding of DNA sequences that do not fully match the guide RNA can limit...

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Bibliografski detalji
Izdano u:Front Mol Biosci
Glavni autori: Mitchell, Brandon P., Hsu, Rohaine V., Medrano, Marco A., Zewde, Nehemiah T., Narkhede, Yogesh B., Palermo, Giulia
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2020
Teme:
Molecular Biosciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7093078/
https://ncbi.nlm.nih.gov/pubmed/32258048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2020.00039
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